Neurology

Thinking ahead for a successful trial

Neuroradiology offers many opportunities for both anatomic and functional assessment throughout a spectrum of neurological diseases. We emphasize successful endpoints through efficient planning at the beginning of your development program, and consultation with your team to identify and prevent some of the challenges that could occur during the course of your study. Neuroimaging provides a wide range of techniques and as such, finely-detailed standardization beforehand is critical to ensuring consistent and reliable data acquisition at your clinical trial imaging sites.

Standardizing acquisition parameters, consistent and closely controlled post-acquisition data processing, and expert analysis are the basis for clinical development program success. There are number of tools that exist to analyze acquired images, but all are not created or employed equally. Imaging Endpoints will work with you to determine the best modality and imaging mix, maximizing the potential for valuable data. Our experts are engaged throughout the process, from protocol design to real-time central image analysis, to ensure the highest quality throughout your trial.

Imaging Endpoints' board-certified and specialty-trained neuroradiologists are available to assist you with your neurological imaging needs, and we partner with a panel of leading clinical neurologists who are heavily engaged in research and are available to help with consultations and other services as needed. Due to the technical challenges of some neurological imaging techniques, we also work with medical physicists as necessary to ensure that your trial is a success.

Areas of imaging specialty include the following: 

Alzheimer's
Alzheimer's/Dementia
Epilepsy
Parkinson's disease
Traumatic brain injury
Spinal interventions
(kyphoplasty, vertebroplasty)

Spinal fusion surgeries
Multiple sclerosis
Neuro-Oncology
(brain tumors, metastatic disease)
Head and neck malignancies
Carotid and cerebral vascular disease
Vascular malformations

Our Neuroradiologists have additional subspecialty training in the following areas:

Brain-demyelinating diseases (eg, MS), dementia (eg, Alzheimer's)
Spine and spinal interventions
Brain tumors
Head and neck malignancies
Traumatic brain injury
Pediatric neuroimaging

Assessments

Our in-house capability includes analyzing both anatomic and functional neuroimaging acquired in clinical trials

 

Anatomic

  • Stroke (ischemic/hemorrhagic) lesion detection
  • MS lesion detection and volumetric quantitation
  • Brain atrophy: quantify and track over serial time points
  • Carotid/Cerebral stenosis
  • Carotid plaque: evaluate morphology
  • Brain tumors: detection and quantitation

Functional

  • Stroke lesion analysis using MRI diffusion-weighted sequences or MR/CT perfusion techniques
  • Alzheimer's detection on PET/CT using a variety of radiopharmaceuticals
  • Brain tumors: MR Perfusion
Modalities
 
  • PET/CT
  • MRI/MRA
  • MR Spectroscopy
  • Diffusion Tensor Imaging (DTI)
  • CT/CTA
  • Ultrasound (carotid vascular imaging)
  • Transcranial/Intracranial Doppler