Imaging Endpoints develops predictor of response for Tracon Pharmaceuticals

SAN DIEGO (GLOBE NEWSWIRE) — TRACON Pharmaceuticals, a biopharmaceutical company that develops targeted therapies for oncology and ophthalmology, today announced data being presented on TRC105 during two poster presentations at the 2013 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics which is taking place October 19-23, 2013 in Boston. TRC105, a novel monoclonal antibody to endoglin (CD105), is being studied in multiple clinical trials in combination with agents that target the VEGF pathway.

On Sunday, October 20, in a poster presentation titled, “Exploratory textural CT evaluation of the combination of TRC105 and bevacizumab (BEV) indicates partial response by Choi criteria in BEV refractory advanced cancer patients and identifies candidate markers of response,” Dr. Ron Korn of Imaging Endpoints Core Lab, Scottsdale, Arizona, presented data on five patients indicating that radiographic partial responses by Choi criteria were observed in patients who had progressed on prior BEV therapy. Qualitative textural analysis identified potential lesion-based predictors of response, and responding lesions tended to have an alteration of hypoxia on baseline CT scans prior to treatment.