RRx-001 is an anticancer agent that subjects cancer cells to reactive oxygen/ nitrogen species (ROS/RNS) and acts as an epigenetic modifier. We have used a thiol-bearing MRI contrast agent, Gd-LC7-SH, to investigate the pharmacodynamics of RRx-001 in CHP-100 Ewing’s Sarcoma,… Read More
Purpose: To determine whether deposition characteristics of ferumoxytol (FMX) iron nanoparticles in tumors, identiﬁed by quantitative MRI, may predict tumor lesion response to nanoli-posomal irinotecan (nal-IRI). Experimental Design: Eligible patients with previously trea-ted solid tumors had FMX-MRI scans before and… Read More
Ramanathan R.K., Korn R.L., Chiorean E.G., Liu H. & Von Hoff D.D. “Positron emission tomography (PET) as a predictive measure in patients with metastatic pancreatic cancer and normal CA19-9 levels at baseline.” Ann Oncol., 00: 1–2, (2016). To read more… Read More
11th Annual TOP Conference – Don’t Forget Clinical Trials Imaging Endpoints CMO and Founder, Ronald Korn, MD., Ph.D. presents “New Imaging Techniques to Aid Creative Clinical Trial Designs.” This talk will cover the role of imaging in oncology clinical trials… Read More
Dr. Ron Korn, founder and Chief Medical Officer of Imaging Endpoints Core Lab will be a featured speaker at the Cancer Treatment Centers of America® (CTCA) Western Regional Medical Center (Western) Annual New Treatments in Oncology (ANTO) conference. This conference focuses on advances in cancer research, new treatments and patient care.
Imaging Endpoints CMO and Founder, Ronald Korn, MD., Ph.D. presents “Imaging the Immune System in Solid Tumors.”This talk will cover the spectrum of immunotherapy from an imaging perspective along with current trends including novel imaging methodologies and enhanced techniques beyond conventional imaging. The Immuno-Oncology 360° eventdelves into key areas of business, clinical and scientific advancements including the Business Aspects for IO, Differences of Modalities in Immunotherapy, Methodological Advances – Investigating Immunotherapies in the Clinic, Immunotherapy Practice Altering Clinical Advances, Hematologic Malignancies, Emerging Biomarkers and Randomized Phase II Combination Therapy Trials. Visit us and learn how we can provide imaging expertise to help develop your product in translational and Phase I studies and provide core lab services for Phase I, II, III and IV. For more information, email us at firstname.lastname@example.org or call us at 480.314.3070.
February 2, 2016 – February 3, 2016
Background: In the phase III MPACT trial, nab-paclitaxel plus gemcitabine (nab-P + Gem) demonstrated superior efficacy versus Gem alone for patients with metastatic pancreatic cancer. We sought to examine the feasibility of positron emission tomography (PET) and to compare metabolic… Read More
Purpose: To investigate whether non–small cell lung cancer (NSCLC) tumors that express high normalized maximum standardized uptake value (SUVmax) are associated with a more epithelial-mesenchymal transition (EMT)–like phenotype. Materials and Methods: In this institutional review board–approved study, a public NSCLC… Read More
Abstract Purpose: This phase Ib study evaluated the safety and tolerability of PEGylated human recombinant hyaluronidase (PEGPH20) in combination with gemcitabine (Gem), and established a phase II dose for patients with untreated stage IV metastatic pancreatic ductal adenocarcinoma (PDA). Objective… Read More
Abstract Objectives To characterize a radiogenomic risk score (RRS), a previously defined biomarker, and to evaluate its potential for stratifying radiological progression-free survival (rPFS) in patients with metastatic renal cell carcinoma (mRCC) undergoing pre-surgical treatment with bevacizumab Methodology In this… Read More