News

August 02, 2017

Purpose:
To evaluate the feasibility of constructing radiogenomic-based surrogates of molecular assays (SOMAs) in patients with clear-cell renal cell carcinoma (CCRCC) by using data extracted from a single computed tomographic (CT) image.

Materials and Methods:
In this institutional review board approved study, gene expression... full article

August 02, 2017

Abstract
Objectives
To characterize a radiogenomic risk score (RRS), a previously defined biomarker, and to evaluate its potential for stratifying radiological progression-free survival (rPFS) in patients with metastatic renal cell carcinoma (mRCC) undergoing pre-surgical treatment with bevacizumab

Methodology
In this IRB-... full article

August 02, 2017

Abstract
Purpose:
This phase Ib study evaluated the safety and tolerability of PEGylated human recombinant hyaluronidase (PEGPH20) in combination with gemcitabine (Gem), and established a phase II dose for patients with untreated stage IV metastatic pancreatic ductal adenocarcinoma (PDA). Objective response rate and treatment... full article

August 02, 2017

Background:
In the phase III MPACT trial, nab-paclitaxel plus gemcitabine (nab-P + Gem) demonstrated superior efficacy versus Gem alone for patients with metastatic pancreatic cancer. We sought to examine the feasibility of positron emission tomography (PET) and to compare metabolic response rates and associated correlations with efficacy... full article

August 02, 2017

Purpose:
To investigate whether non–small cell lung cancer (NSCLC) tumors that express high normalized maximum standardized uptake value (SUVmax) are associated with a more epithelial-mesenchymal transition (EMT)–like phenotype.

Materials and Methods:
In this institutional review board–approved study, a public NSCLC data set... full article

August 02, 2017

Purpose:
To determine whether deposition characteristics of ferumoxytol (FMX) iron nanoparticles in tumors, identified by quantitative MRI, may predict tumor lesion response to nanoli-posomal irinotecan (nal-IRI).

Experimental Design:
Eligible patients with previously trea-ted solid tumors had FMX-MRI scans before and... full article

August 02, 2017

RRx-001 is an anticancer agent that subjects cancer cells to reactive oxygen/ nitrogen species (ROS/RNS) and acts as an epigenetic modifier. We have used a thiol-bearing MRI contrast agent, Gd-LC7-SH, to investigate the pharmacodynamics of RRx-001 in CHP-100 Ewing’s Sarcoma, HT-29 colorectal carcinoma, and PANC-1 pancreatic carcinoma... full article

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